Jie Dong

admin 发表于 2015-11-30 14:54

Jie Dong, Ph. D.

Tel: 1354****180

Address: Changsha, Hunan, China

E-mail: biomed@csu.edu.cn

Homepage: http://home.scbdd.com

Personal page:

https://scholar.google.com/citations?user=phFGEecAAAAJ&hl=en

https://www.researchgate.net/profile/Jie_Dong7

Education background

2008.09-2012.06                                             Central South UniversityBachelor

2012.09-2017.11                                             Central South UniversityPh.D.

MajorMedicinal Chemistry (Cheminformatics and Drug Design)

Major Courses: Medicinal Chemistry; Pharmaceutics; Pharmaceutical Analysis; Biopharmaceuticals and Pharmacokinetics; Pharmacotherapeutics;

Organic Chemistry; Analytical Chemistry; Pharmacognostics; Microbiology; Biochemistry; Molecular biology.

Skills certificate 

National College English Test (CET6)

National Computer Rank Examination(NCRELevel II: VB)

The Primary Pharmacist License of Ministry of Health

Certificate of the GCP Training

Professional expertise

Drug Design: Be skilled with ligand-based drug design (Molecular Operation, Molecular Similarity, Quantitative Structure-Activity Relationship (QSAR) Study, Virtual Screening,  et al.) and receptor-based drug design (e.g., Docking). Can use these technologies to solve problems in drug discovery including target screening, activity prediction, ADMET property prediction, Lead compound generation and optimization.

Artificial Intelligence and Data Mining: Be familiar with commonly used statistical and machine learning algorithms (PLS, RF, SVM, DT, KNN, et al.). Can apply these methods and technologies into drug target discovery, drug design, modeling and prediction in pharmacokinetics, and computational medicine area. Be skilled with mining big data through programming technology and algorithms. Can quickly select bioactive lead compounds in mass data, and achieve rapid diagnosis and evaluation for complex disease systems.

Interdisciplinary Skills :Can solve specific problems in interdisciplines by means of Cheminformatics and Bioinformatics methods and tools, such as target prediction of natural products, multi-target mechanism research of traditional Chinese medicine, data analysis of radiomics and theoretical calculation of small molecule probes.

Computer Skills and Application: Be familiar with and master several popular programming languages, such as Python, HTML, CSS, JavaScript, PHP and SQL. Can use these skills to realize kinds of development of content management system, databases, computing/analyzing platforms, scientific packages and tools.

Research areas

 Computer aided molecular design based on artificial intelligence system and system pharmacology;

Software, web services and database development in process of system biology and drug discovery;

Development of structure-based virtual screening methods

Predictions of ADMET and drug-likeness

Research projects

Preside over 2016 the Hunan Provincial Innovation Foundation for PostgraduateConstruction of a platform for predicting drug-target interaction based on chemical biological methods; Grants No.: CX2016B058; Amount: 30,000¥.

Participate in 2011 Innovative training program for college students of Central South UniversityThe design and reevaluation of prodrug: VBE-1 which is a PI3K/Akt/mTOR pathway inhibitor; Grants No.: CL11249; Amount: 3,000¥.

Participate in the project of NSFCMulti-scale based system biology method to predict drug side effects interaction networks; Grants No.: 81402853

●  Participate in the project of NSFC: Construction of a novel molecular probe with high affinity selection and its diagnosis and treatment of rheumatoid arthritis; Grants No.: 81671756

Participate in the project of NSFC: Construction of an image probe of sulfonyl sulfonyl molecules and its application in cell apoptosis imaging; Grants No.: 81671234

Participate in Innovation Drive Program of Central South UniversityMulti-scale based network pharmacology on drug target network prediction and drug redirection study; Grants No.: 90700-505019119

Conferences

In November 2017, attend the 14th Fourteenth National Conference on Computing (Computer) Chemistry, Location: Nanjing University, The poster and oral presentation;

In July 2016, attend The 30th annual conference of the Chinese Chemical AssociationLocation: Dalian University of Technology, Poster Presentation

In October 2016, Conference on Medicinal Chemistry in Central China and Frontier Science Seminar on International Pharmacy, Location: Wuhan University

In July 2015, attend the 14th Fourteenth National Conference on Computing (Computer) Chemistry, Location: Sun Yat-sen University, Poster Presentation

Publications

[1] Dong J, Cao D S, Miao H Y, et al. ChemDes: an integrated web-based platform for molecular descriptor and fingerprint computation[J].Journal of Cheminformatics, 2015, 7(1): 1-10. (First author, JCR: Q1, IF: 4.22)

[2] Dong J, Yao Z J, Zhu M F, et al. ChemSAR: an online pipelining platform for molecular SAR modeling[J]. Journal of Cheminformatics, 2017, 9(1): 1-13. (First author, JCR: Q1, IF: 4.22)

[3] Dong J, Yao Z J, Wen M, et al. BioTriangle: a web-accessible platform for generating various molecular representations for chemicals, proteins, DNAs/RNAs and their interactions[J]. Journal of Cheminformatics, 2016, 8(1): 1-13. (JCR: Q1, IF: 4.22)

[4] Dong J, Wang N N, Liu K Y, et al. ChemBCPP: A freely available web server for calculating commonly used physicochemical properties[J]. Chemometrics and Intelligent Laboratory Systems, 2017, 171: 65-73(JCR Q1, IF: 2.22)

[5] Wang N N*, Dong J*, Deng Y H, et al. ADME properties evaluation in drug discovery: prediction of Caco-2 Cell permeability using a combination of NSGA-II and boosting[J].Journal of Chemical Information and Modeling, 2016, 56(4): 763-773. (JCR Q1, IF: 3.76)

[6] Yao Z J*, Dong J*, Che Y J, et al. TargetNet: a web service for predicting potential drug-target interaction profiling via multi-target SAR models[J].Journal of Computer-Aided Molecular Design, 2016, 30(5): 413-424.(JCR: Q1, IF: 3.02)

[7] Dong J, Liu S, Zhu X L, et al. Ti-AI intermetallic compound membrane refining Chinese medicinal materials extract[J]. Journal of Chinese Medicinal Materials, 2014, 37(9): 1673-1675. (CSCD core journal)

[8] Cao D S, Dong J, Wang N N, et al. In silico toxicity prediction of chemicals from EPA toxicity database by kernel fusion-based support vector machines[J]. Chemometrics and Intelligent Laboratory Systems, 2015, 146: 494-502. (JCR: Q1IF: 2.22)

[9] Wang N N, Huang C, Dong J, et al. Predicting human intestinal absorption with modified random forest approach: a comprehensive evaluation of molecular representation, unbalanced data, and applicability domain issues[J]. RSC Advances, 2017, 7(31): 19007-19018. (JCR: Q2, IF: 3.10)

[10] Gao T, Cao X, Dong J, et al. A novel water soluble multifunctional fluorescent probe for highly sensitive and ultrafast detection of anionic surfactants and wash free imaging of Gram-positive bacteria strains[J]. Dyes and Pigments, 2017, 143: 436-443. (JCR: Q1, IF: 3.47)

[11] Yang S, Gao T, Dong J, et al. A novel water-soluble AIE-based fluorescence probe with red emission for the sensitive detection of heparin in aqueous solution and human serum samples[J].Tetrahedron Letters, 2017, 58(37): 3681-3686. (JCR: Q2, IF: 2.19)

[12] Wang N N, Deng Z K, Huang C, Dong J, et al. ADME properties evaluation in drug discovery: Prediction of plasma protein binding using NSGA-II combining PLS and consensus modeling[J].Chemometrics and Intelligent Laboratory Systems, 2017, 170: 84-95. (JCR: Q2, IF: 2.22)

[13] Wang Y, Huang J J, Zhou N, Dong J, et al. Incorporating PLS model information into particle swarm optimization for descriptor selection in QSAR/QSPR[J]. Journal of Chemometrics, 2015, 29(12): 627-636. (JCR: Q2, IF: 1.87)

[14] Gao T, Cao X, Ge P, Dong J, et al. A self-assembled fluorescent organic nanoprobe and its application for sulfite detection in food samples and living systems[J].Organic & Biomolecular Chemistry, 2017, 15(20): 4375-4382. (JCR: Q1, IF: 3.56)

[15] Cao D S, Deng Z K, Zhu M F, Dong J, et al. Ensemble partial least squares regression for descriptor selection, outlier detection, applicability domain assessment, and ensemble modeling in QSAR/QSPR modeling[J]. Journal of Chemometrics, 2017, 31(11): e2922. (JCR: Q2, IF: 1.88)

[16] Gao T, Yang S, Cao X, Dong J, et al. Smart self-assembled organic nanoprobe for protein-specific detection: design, synthesis, application, and mechanism studies[J]. Analytical Chemistry, 2017, 89(18): 10085-10093. (JCR: Q1, IF: 6.32)

[17] Bi A, Gao T, Cao X, Dong J, et al. A novel naphthalimide-based probe for ultrafast, highly selective and sensitive detection of formaldehyde[J]. Sensors and Actuators B: Chemical, 2018, 255(3): 3292-3297. (JCR: Q1, IF: 5.40)

Awards

In 2016, won the Top-notch Doctoral Scholarship (16 places in total);

In 2016, won the "top ten" PhD of Central South University (10 places in total);

In 2016, won the Graduate National Scholarship;

In 2017, won the "Lu Huilin" Award of Central South University;

In 2015, won the annual best monitor of Central South University;

In 2015, won the "Lu Huilin" Award of Central South University;

In 2015, won the annual "Excellent Communists";

In 2015-2016, won the Outstanding postgraduate cadres of Central South University;

In 2014-2015, won the Outstanding postgraduate cadres of Central South University;

In 2012, won the first prize of "Thanksgiving first" in Central South University;

In 2012, won the first prize of "Thanksgiving first" in Xiangya School of Medicine;

In 2009-2010, won the "excellent director" of the League Committee of my University;

In 2009-2010 won the "excellent cadre" of the League Committee of my University;

In 2009-2010 won the "single award" of the comprehensive evaluation of my college;

In 2009 won Lei Feng's spiritual speech winning awards of my University;

In 2008-2009 won the "third award" of the comprehensive evaluation of my college;

In 2008-2009 won the "excellent student cadre" of Central South University.

Representative achievements

ChemDes

URL: http://www.scbdd.com/chemdes

Description: An integrated web-based platform for molecular descriptor and fingerprint computation.

 

ChemSAR

URL: http://chemsar.scbdd.com

Description: an online pipelining platform for molecular SAR modeling.

 

 

PyNetSim

URL: http://pynetsim.scbdd.com

Description: generating various network-based node similarity indices in network inference schemes.

 

 

ChemBCPP

URL: http://chembcpp.scbdd.com

Description: A freely available web server for calculating commonly used physicochemical properties.

 

 

BioMedR

URL: http://bioconductor.org/packages/BioMedR/

Description: an R/Bioconductor package linking the chemical, protein and DNA/RNA space in view of molecular representation.

 

 

BioTriangle

URL: http://biotriangle.scbdd.com

Description: a web-accessible platform for generating various molecular representations for chemicals, proteins, DNAs/RNAs and their interactions.

 

 

TargetNet

URL: http://targetnet.scbdd.com

Description: a web service for predicting potential drug-target interaction profiling via multi-target SAR models.

 

 

ADMETlab

URL: http://admet.scbdd.com

Description: a platform for systematic ADME/T property evaluation based on a comprehensive database.

 

HAMDB

URL: http://hamdb.scbdd.com

Description: A database providing the up-to-date information of existing autophagy-related modulators (proteins, chemicals and microRNA) including their specific effect on autophagy, pathway and disease information.

 

GPCRnet

URL: http://gpcrnet.scbdd.com

Description: a web server that could be used for netting or predicting the binding of multiple GPCR targets for any given molecule.